Brands And Manufacturers

 Etizolam, ( also known by brand names “Etibest”, “Etilaam”, “Etizoma”, “E1”, “Etilite”, “ETINEX”, “Etipax”, “Etirest”, “Etizola”, “Etizola Beta”, “Etizola MD”, “Etweet”, “Inxity”, “Lam ET”, “Macfresh”, “New Zomania”, “Sylkam”, “Zolacalm”, “Zoly” and “Etizeal” ) is manufactured by a variety of pharmacutical companies.
These companies include but are not limited to:
  • Macleods(Procare CV)
  • Macleods Pharmaceuticals Pvt Ltd
  • Tweet India
  • Archicare
  • Tas Med (I) Pvt. Ltd
  • Macleods (TB care)
  • Molekule,
  • Dr. Reddy’s
  • Phoenix
  • Grownbury Pharmaceuticals Pvt. Ltd
  • Sun Pharmaceuticals Industries Ltd
  • Intas Pharmaceuticals Ltd
  • Aarpik
  • Concern Pharmaceuticals Pvt
  • Kachhela Medex Private Limited
  • Tripada Biotech Pvt. Ltd

Etizolam is a chemical substance or compound that has various physiological and biochemical effects on our bodies. Some of these effects are similar to the ones produced by benzodiazepines, like:

  • Alprazolam (“Xanax”)
  • Clonazepam (“Klonopin”)
  • Diazepam (“Valium”)

If one were to consume it, they can expect the usual benzodiazepine-like anxiety suppression, sedation, and extreme memory suppression that accompanies benzodiazepine use.

Etizolam is generally taken orally, but sublingually is also a popular method due to the increased bioavailability.

As you would expect, Etizolam is commonly prescribed to treat cases of insomnia and anxiety in the same exact fashion as benzodiazepines.

However, this practice only happens to be popular in certain sectors of the world. ( Such as Japan and India )

In the United States, Etizolam is considered a research chemical and has become a benzodiazepine substitute for man. ( Which makes sense due to its availability online compared to it’s scheduled benzodiazepine counter-parts. )

Chinese vs Pharmaceutical Grade

Most people purchase Etizolam online through a domestic research chemical vendor that has gotten it from a Chinese manufacturer.

This problem with this method is the severe lack of quality control, and often times, receiving a chemical that is not Etizolam at all.

The other issue with this method is the fact that most people don’t have access to the necessary lab equipment needed in order to weigh Etizolam accurately.

If the user is ordering Etizolam for consumption then this can pose a variety of problems, such as consumption of a chemical that is not Etizolam at all.

There have been various reports of people receiving the wrong compound from Chinese manufacturers. ( like a Fentanyl Analog )

Even worse, people have died from the chemical in question because they thought it was Etizolam or some other chemical that they have ordered over the internet.

This is why it’s extremely important to NEVER consume raw powder material without first sending it to a lab for analysis and verification of its chemical identity.

Another option is choosing to only purchase pharmaceutical grade Etizolam from a licensed manufacturer who has packaged the product themselves into sealed blister packs and have quality control systems in place to guarantee the purity and dosage of every pressed pill.

Commonly, Chinese quality Etizolam powder is laid onto blotter paper or pressed into tablets by the research chemical vendor.

Unless the vendor has a certificate of analysis to prove that the contents inside of the product are what they say they are, you should avoid it at all costs.

( And even if the research chemical vendor provides a COA, one should still avoid the product if they have a pharmaceutical grade vendor available )

Just because the research chemical vendor sent their product in to get it tested doesn’t mean they didn’t add anything to it afterward or trade it out for something else in order to help boost their profit margin.

The Potency of Etizolam

Now, as for relative potency, 1mg of Etizolam is said to be approximately the same as 0.5 mg of alprazolam ( Xanax ), 0.5 mg of clonazepam ( Klonopin ), or 10mg of diazepam ( Valium ).

It is often touted as being slightly less sedating and potent as alprazolam.

Before we really begin digging deep into Etizolam, you should also be aware that the discontinuation of thienodiazepines ( like Etizolam ) can be dangerous and even deadly for people who have been using the compound consistently for long periods of time.

Suddenly stopping use can result in fatal seizures and should be avoided at all costs. ( This may remind you of the characteristics of benzodiazepines )

If you find yourself physically dependent on benzodiazepines or thienodiazepines, then it is highly recommended that you use a tapering strategy.

You can do this by gradually lowering your dosage each day over a prolonged period of time instead of abruptly stopping cold turkey. ( to stop completely )

The History

Etizolam was first introduced into the research chemical scene in 2011. It quickly rose to fame as a cheaper, easier to access alternative to benzodiazepines for the treatment of insomnia and anxiety.

However, there are medical papers citing that it’s been used as early as the 1990s in treating anxiety.

As a relatively new research chemical, Etizolam is unique because it is approved and is being actively prescribed as a mental treatment for anxiety and insomnia in many countries throughout the world.

It is manufactured and sold under the common brand names such as Etibest, Etilaam, and Etizest.

The Chemistry

As you may or may not know, Etizolam is a thienodiazepine because the bezene ring has been substituted for the thiophene ring. The thiopene ring is aromatic and contains one sulfur atom.

The thiopene aromatic ring is fused with diazepine ( a seven-membered ring that has two nitrogens located at R1 and R4 ) which creates the thienodiazepine core that Etizolam contains.

Also, a chlorine-substituted phenyl ring is bound at R5 and an ethyl chain is bound at R7.

Additionally, Etizolam has a methylated triazole ring fused to its diazepine ring. This triazole ring is shared with other benzodiazepines, which are called triazolobenzodiazepines.

The Pharmacology

As for the pharmacology of Etizolam, it produces a huge range of effects by binding to the benzodiazepine receptor sites and increasing the and increasing the efficiency of the neurotransmitter GABA.

Modifying these receptor sites with the use of thienodiazepines result in calming, sometimes even sedating effect on the nervous system.

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The Subjective Effects

Below are the effects of Etizolam, which is based on the personal experiences of others and the subjective effects index.

The effects listed below are generalized and are highly reliant on what dosage of Etizolam was taken.

The heavier the dose you take, the more likely that you’ll experience the full range of effects.

However, you also increase the potential for adverse effects such as injury or death.

Physical Effects of Etizolam

Sedation – Etizolam is known to cause sedation at relatively low dosages. It can feel as if the user needs to suddenly take a nap.

However, in higher doses ( depending upon tolerance level ) the user can quickly find themselves completely unconscious.

This can be very dangerous because the user’s body could still be active while the mind is missing in action.

Euphoria – While people may not find Etizolam ‘euphoric’ in the traditional sense of the word, many others still do.

This is mainly due to the loss of inhibitions that come from consuming substances like Xanax, Etizolam, Valium, Klonopin etc.

The euphoric effects may be associated with loss of anxiety, worry, fear and overall relaxation of the mind/body.

Motor Control Loss – During higher doses of Etizolam, you may begin to experience severe loss of coordination.

This effect is similar to when someone drinks too much alcohol and now stumbles everywhere, no longer able to form coherent, logical sentences.

Respiratory Depression – Because Etizolam has depressant effects upon the nervous system, users find that their breathing may become more shallow.

This effect can become amplified to extremely dangerous ( deadly ) levels if one were to mix other depressants ( such as alcohol, heroin etc. ) with it.

*WARNING: DO NOT mix depressants with other depressants, the risk of death is very high when doing so*

Increased Libido – Some find that ingestion causes an increase in feelings of sexual desire.

This may stem from the user becoming more aware of how they feel in regards to sex and thus, may not literally increase sexual desire.

Muscle Relaxation – Arguably one of the most sought-after effects of Etizolam, muscle relaxation may increase to levels that rival actual muscle relaxers ( like Soma ).

This effect increases in correspondence to dose and seems to reach a peak level before potentially unwanted side effects begin to manifest themselves as drunken stupor.

Seizure Suppression – Thienodiazepines, along with benzodiazepines, have a unique quality of reducing seizure thresholds.

However, abrupt discontinuation of these substances may result in more seizures rather than suppression of seizures.

Due to this, it is highly recommended that one follows a tapering strategy when wanting to discontinue use with these compounds.

Appetite Enhancement – This effect is particularly notable when combining other substances such as cannabis.

One may find that their appetite is increased more so than if they were to use either substance alone.

Cognitive Effects of Etizolam

Anxiety Suppression – Etizolam’s anti-anxiety effects is what makes it so appealing to most users.

Anxiety seemingly melts away into nothing, leaving the user with a blissful feeling of, “no longer worrying”.

Compulsive Redosing – Because Etizolam doesn’t last very long, many users find a compulsion to re-dose and achieve the desired anti-anxiety effects.

Memory Suppression –  If too intoxicated, the user often forgets that they’ve consumed more and proceed to re-dose until they reach a danger blackout state that causes amnesia.

Ego Inflation – When all anxiety is removed there are no longer any boundaries holding someone back from saying how they feel.

This may also be due to the lack of consciousness when consuming higher amounts.

Motivation Suppression – Due to Etizolam’s effects on one’s energy levels, the user may no longer feel motivated to do anything while intoxicated.

Emotionality Suppression – Under the effects of Etizolam, the user may find it difficult to care about their problems.

Sleepiness – Compounds that work with the neurotransmitter GABA are known to cause states of extreme drowsiness.

After Effects of Etizolam

Rebound Anxiety – Using anxiety reducing substances like Etizolam and benzodiazepines often have rebound effects after taking them for so long.

These rebound effects cause more anxiety in the user than when they began using Etizolam and provokes the user to use more in order to momentarily get rid of the rebound anxiety.

Dream Suppression – During one’s use of thienodiazepines, one may find it harder to dream.

Dream Potentiation – Alternatively, one may find it easier to dream and is highly dependant on the user.

Residual Sleepiness – Etizolam, and benzodiazepines like it are often used to treat insomnia.

However, there may be after effects the morning after where the user feels extremely “groggy”.

Thought Deceleration – Thinking processes are slowed to a halt when using this substance. This may be euphoric to the user who can never slow their thoughts.

Thought Disorganization – When using higher doses of Etizolam the user will find that their train of thought is severely impaired.

Irritability – Though calming while experiencing the effects, the comedown can produce irritability in users.

Preparation Methods

Volumetric Liquid Dosing – If one doesn’t get pharmaceutical grade Etizolam pellets from a verified manufacturer or vendor then you need a way to accurately measure your Etizolam in powder form.

Without lab-grade analytical scales, it is unlikely to happen unless you use a method called volumetric measurement.

You can do this and avoid the risk of overdose by dissolving the thienodiazepine into a carrier solution like propylene glycol to get a more accuracte measurement of your intended dosage.

Experience Reports

These are reports from users that describe the effects of this compound:   

A Low Dose Awoke Feeling Refreshed Stronger Than You’d Think
Conversation Just Flowed Holy Hell That Potency Liquid Bliss
Pipedream Walker Overthinking Social Anxiety Great While It Lasts
Just A Nice Mood Enhancer More Then I Expected Fun While It Lasts
Mellow With Less Amazing – No Other Words Conversation Just Flowed

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  1. Nick December 19, 2017
    • The Yeti December 21, 2017

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